Potential overexpression of a microglial recruitment chemokine, MCP-1 (Monocyte Chimioattractant Protein 1), by motor neurons themselves could mediate this process.
Studies on spinal cord appear to be relevant for risk assessment of population exposed via contaminated food and water.
This observation was correlated with a decreased number of motor neurons in the highly contaminated group and a decrease of SMN1 protein expression (Survival of Motor Neuron 1).
While contamination impairs motor neuron integrity, an increasing number of microglial cells indicates the trigger of a neuroinflammation process.
We find that Dclk1 tuft cells and nerves are the main sources of acetylcholine (ACh) within the gastric mucosa.
Cholinergic stimulation of the gastric epithelium induced nerve growth factor (NGF) expression, and in turn NGF overexpression within gastric epithelium expanded enteric nerves and promoted carcinogenesis.
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